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. 2020 Dec 4;11:593647. doi: 10.3389/fphar.2020.593647

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Copyright © 2020 Watanabe, Komiyama, Yoshizumi, Sakurada and Mizoguchi

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The antinociceptive effect of morphine in the inflammatory pain state. Groups of mice pretreated i.pl. with 50 µL of saline or CFA in the left hind paw were injected s.c. with morphine (5 mg/kg) at 1 (A), 3 (B), 5 (C) or 7 days (D) after i.pl. pretreatment; the withdrawal threshold in response to thermal stimulation of the plantar surface of each hind paw was measured for 180 min. Each value represents the mean ± S.E.M. for eight mice. *p < 0.05 vs. ipsilateral paw in the control model (i.pl. saline pretreatment) mice.