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Elastic net (EN) penalized Cox proportional hazards regression from ATE datasets. (A) Pearson correlation between z-scored expression of each gene in the signature in the combined ATE dataset; (B, C) Kaplan–Meier plots for overall survival in the biomarker-evaluable population for the EN signature stratified by median, for all ATE cohorts together (B), and per trial (C). P-value corresponds to Cox proportional hazards model.
