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. 2020 Dec 17;139(2):240–242. doi: 10.1001/jamaophthalmol.2020.5594

Table. Time Course of Intravitreal Anti–Vascular Endothelial Growth Factors Reimbursements Between the 2 Weeks Preceding Lockdown Through the First 4 Weeks of Reopening in the Coronavirus Disease 2019 Pandemic.

Week No. Patients in 2020, No. Difference of observed − expected, No. (%)
Observed Expected
Period before lockdown
Week 10 (March 2-8) 16 114 16 171 −57 (−0.4)
Week 11 (March 9-15) 17 178 17 386 −208 (−1.2)
Total 33 292 33 557 −265 (−0.8)
Female, % 20 146 (60.5) 20 372 (60.7) NA
Age, mean (SD), y 77.3 (11.1) 77.1 (11.1) NA
New users, No.a 2993 3128 −135 (−4.3)
Lockdown period
Week 12 (March 16-22) 14 978 17 318 −2340 (−13.5)
Week 13 (March 23-29) 10 118 16 751 −6633 (−39.6)
Week 14 (March 30-April 5) 8345 15 777 −7432 (−47.1)
Week 15 (April 6-12) 9099 17 294 −8195 (−47.4)
Week 16 (April 13-19) 9018 16 355 −7337 (−44.9)
Week 17 (April 20-26) 11 199 16 209 −5010 (−30.9)
Week 18 (April 27-May 3) 11 199 16 209 −5010 (−30.9)
Week 19 (May 4-10) 13 360 17 784 −4424 (−24.9)
Total 87 316 133 697 −46 381 (−34.7)
Female, % 52 461 (60.1) 82 069 (61.4) NA
Age, mean (SD), y 76.8 (11.0) 77.2 (11.1) NA
New users, No.a 4343 12 512 −8169 (−65.3)
Reopening period
Week 20 (May 11-17) 15 188 19 435 −4247 (−21.9)
Week 21 (May 18-24) 15 531 18 174 −2643 (−14.5)
Week 22 (May 25-31) 16 484 17 207 −723 (−4.2)
Week 23 (June 1-7) 15 817 16 398 −581 (−3.5)
Total 63 020 71 214 −8194 (−11.5)
Female, % 38 593 (61.2) 43 828 (61.5) NA
Age, mean (SD), y 77.5 (11.0) 77.3 (11.1) NA
New users, No.a 4463 4692 −229 (−4.9)

Abbreviations: NA, not applicable.

a

New use of intravitreal anti–vascular endothelial growth factors was defined by the absence of any such reimbursement during the previous year.