Table 2. Clinical Presentation and Management of ONJ Cases.
| Factor | Patient data (n = 90)a |
|---|---|
| Initial presentation | |
| Stageb | |
| 0 | 5 (6.4) |
| 1 | 46 (59.0) |
| 2 | 22 (28.2) |
| 3 | 5 (6.4) |
| Gradec | |
| 1A | 18 (23.4) |
| 1B | 3 (3.9) |
| 2A | 22 (28.6) |
| 2B | 5 (6.5) |
| 3A | 22 (28.6) |
| 3B | 2 (2.6) |
| 4A | 2 (2.6) |
| 4B | 3 (3.9) |
| Infection signs or symptoms | |
| No | 48 (63.2) |
| Yes | 28 (36.8) |
| No. of lesions, median (IQR) | 1 (1-1) |
| ONJ management | |
| Procedures | |
| No | 16 (20.3) |
| Yes | 63 (79.7) |
| Rinses | |
| No | 31 (39.2) |
| Yes | 48 (60.8) |
| Antibiotics | |
| No | 46 (58.2) |
| Yes | 33 (41.8) |
| Cultures taken | |
| No | 79 (100) |
| Yes | 0 |
| Dental imaging | |
| No | 62 (78.5) |
| Yes | 17 (21.5) |
| Debridement | |
| No | 65 (82.3) |
| Yes | 14 (17.7) |
| Biopsy | |
| No | 74 (93.7) |
| Yes | 5 (6.3) |
| Invasive procedure | |
| No | 75 (94.9) |
| Yes | 4 (5.1) |
| Other | |
| No | 69 (87.3) |
| Yes | 10 (12.7) |
Abbreviations: IQR, intraquartile range; ONJ, osteonecrosis of the jaw.
Unless otherwise indicated, data are expressed as number (percentage) among those with known data. Percentages have been rounded and may not total 100.
Zero indicates no evidence of necrotic bone but nonspecific signs and symptoms; 1, asymptomatic, exposed necrotic bone without evidence of infection; 2, exposed, necrotic bone with infection (pain and erythema with or without purulence); and 3, exposed, necrotic bone associated with pain and infection and 1 or more of the following: necrotic bone extending beyond the alveolar ridge, pathologic fracture, extraoral fistula, oral antral/oral nasal communication, or osteolysis extending to the inferior border of the mandible or the sinus floor.
Graded by lesion size, where 1A (1B if multiple lesions with largest of this size) indicates single lesion less than 0.50 cm; 2A (2B if multiple lesions with largest of this size), single lesion of 0.50 to 0.99 cm; 3A (3B if multiple lesions with largest of this size), single lesion of 1.00 to 2.00 cm; and 4A (4B if multiple lesions with largest of this size), single lesion greater than 2.00 cm.