Fig. 7.

Sepsis severity after 14 days of Syk inhibitor treatment in sepsis mice. Characteristics of FcgRIIb^−/− or wild-type (WT) mice aged 24 and 40 weeks before and after cecal ligation and puncture (CLP) surgery and 14 days after Syk inhibitor administration (Syk inh) or PBS control by survival analysis (a–c) (n = 10 and 16/group for a and b, respectively), serum creatinine (d–f), serum alanine transaminase (g–i), and serum anti-dsDNA antibodies (j–l) (n = 5–7/group for d–l). c, f, i, l show better visualization of the difference in sepsis between FcgRIIb^−/− mice aged 24 and 40 weeks.