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. 2020 Dec 16;6(4):2055217320981396. doi: 10.1177/2055217320981396

Figure 4.

Figure 4.

CSF NfL levels are elevated in ICXCL13+ MS patients. NfL concentrations (pg/ml) in CSF of NIND controls and total MS patients (a) and MS patients analyzed by OCB (b), activity determined by follow-up of ≥ 0.5 years (c), and ICXCL13 (d) negativity or positivity. MS patient subtypes indicated by the following symbols: RIS (○), CIS (▲), RRMS (◊), and PMS (×). Bars indicate median values. Line indicates optimal cut-off of >1105 pg/ml (sensitivity 67%, specificity 69%) for determining elevated NfL levels as determined by ROC analysis comparing MS activity-negative and MS activity-positive patients. P values were determined using a Mann Whitney U test (A) comparing NIND vs total MS (** p < 0.01), RRMS (## p < 0.01), or PMS (^ p < 0.05) and a Kruskal Wallis one-way analysis of variance and Dunn’s multiple comparison test (b–d) comparing NIND, MS activity-negative (MS Activ-), and MS activity-positive (MS Activ+) patient groups (Adjusted p values indicated as * p < 0.05; ** p < 0.01; **** p < 0.0001).