Figure 3.

Spontaneous microhemorrhage formation after heparin administration in 19-month-old APP/PS1 mice. Spontaneous extravasations were not observed in 8-month-old Tg APP/PS1 mice (b) or their WT littermate controls (a), and only occasionally after heparin administration (c). At 19 months of age, both Tg APP/PS1 mice (e) and their WT littermate controls (d) had evidence of spontaneous extravasation (f, χ² test p = 0.30). Subsequent heparin administration resulted more often in extravasations in Tg compared to WT mice (f, χ² test p = 0.039). Lines in C and F indicate median. Note that each dot or triangle in C and F represents a mouse. *p < 0.05.