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. Author manuscript; available in PMC: 2020 Dec 18.
Published in final edited form as: Nature. 2020 May 27;583(7814):145–149. doi: 10.1038/s41586-020-2335-4

Extended Data Figure 5: The voltage-sensing domain of KAT1em in the ‘up’ conformation.

Extended Data Figure 5:

a, Diagram of key VSD features, showing hydrophobic gasket (F102 and V70, yellow) as well as all S4 charges (blue) and distributed countercharges/counter-dipoles (red). b, c, Overlays of KAT1em (tan) with HCN (green, PDB ID: 5U6O) and Kv1.2/2.1 (pink, PDB ID: 2R9R), respectively, highlighting structural differences between S4 helices. Cα atoms of the positively charged residues of S4 are shown as spheres.