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. 2020 Dec 18;4:71. doi: 10.1186/s41927-020-00168-x

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 1 — Pain intensity and temporal aspect of pain. a Pain intensity including current, average and maximum pain levels of either total AID patients or NLRP3, MEFV and TNFRSF1A low penetrance variants alone are plotted on a numeric ranging scale (0 = no pain, 10 = maximum conceivable pain). Error bars indicate standard error of the mean. White columns: all patients; light grey columns: NLRP3; grey columns: MEFV, and dark grey columns: TNFRSF1A low penetrance variants. b Pain episodes of all patients (white columns), NLRP3 (light grey columns), MEFV (grey columns) and TNFRSF1A (dark grey columns) low penetrance variants alone are categorized as follows: persistent pain, recurrent attacks with asymptomatic intervals or attacks with persistent pain in between. Data are shown as relative numbers in percent (%)