Table 3.
Pain characteristics
| Patient number/age/sex/origin | Low penetrance variants/mutations | Localization of pain | Sensory qualities of pain | Affective pain quality summary score | Pain trigger/ intensifying factors | Pain relieving factors | Pain severity according to Korff | Dis-ability score | Dis-ability days | De-pression score | Anxiety score | Actual analgetic therapy |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1/68/F/C | Q703K (+/−) NLRP3 gene (exon 3) | – | – | – | – | – | – | 0 | 0 | 13 | 6 | none |
| 2/52/F/C | Q703K (+/−) NLRP3 gene (exon 3); R92Q (+/−) TNFRSF1A gene (exon 4) | arms, legs, abdominal | dragging, burning | 1 | bacterial/viral infection, mental stress, injury | relaxation, yoga, physiotherapy | I | 0 | 10 | 1 | 6 | ibuprofen, diclofenac, acetylsalicylic acid, paracetamol |
| 3/60/F/C | Q703K (+/−) NLRP3 gene (exon 3) | head, thoracic, lower back, shoulder, arms, hands, legs, feet, abdominal | dull, stabbing, dragging, burning | 9 | mental stress | take a walk, sleeping | IV | 3 | 8 | 10 | 16 | ibuprofen, steroids |
| 4/33/M/C | Q703K (+/−) NLRP3 gene (exon 3) | head, cervical, shoulder | dull, stabbing, dragging | 6 | coldness, mental stress | relaxation, stretching | III | 3 | 5 | 3 | 7 | none |
| 5/63/F/C† | Q703K (+/−) NLRP3 gene (exon 3) | lower back, shoulder, pelvic area, legs, feet, | pulsatile, throbbing, stabbing, dragging, burning | 4 | n.k. | physio-, ergo-therapy, sleeping, exercising | IV | 3 | 90 | 8 | 11 | none |
| 6/52/F/C | Q703K (+/−) NLRP3 gene (exon 3) | head, lower back, shoulder, arms, hands, pelvic area, legs, feet | dull, dragging | 6 | mental stress | exercising, stress prevention, sleep, relaxation | III | 1 | 12 | 3 | 4 | none |
| 7/40/F/C | Q703K (+/−) NLRP3 gene (exon 3) | pelvic area | dragging | 1 | fatigue, mental stress | relaxation, medication | I | 0 | 0.5 | 11 | 8 | tramadol, ibuprofen, paracetamol, diclofenac |
| 8/47/F/C | Q703K (+/−) NLRP3 gene (exon 3) | head, cervical, thoracic, lower back, shoulder, pelvic area, legs | dull, dragging, burning | 1 | coldness, physical stress | sleep, exercising, change in climate | IV | 2 | 30 | 3 | 5 | none |
| 9/59/F/C | Q703K (+/−) NLRP3 gene (exon 3) | head, shoulder, arms, hands, pelvic area, legs, feet | stabbing, dragging | 6 | coldness | no influence-able factors are known | IV | 3 | 20 | 19 | 12 | ibuprofen |
| 10/29/M/C | V726A (+/−) MEFV gene (exon 10) | head, cervical, abdominal | dragging | 7 | stress | tranquility, mediaction | III | 1 | 10 | 2 | 3 | none |
| 11/49/F/C |
I591T (+/−) MEFV gene (exon 9) |
head, hands, abdominal | dull | 5 | food | nutrition, tranquility, warmness | I | 0 | 0 | 2 | 7 | ibuprofen |
| 12/23/F/C | unknown | cervical, shoulder, chest | dull, pulsatile, stabbing | 9 | over-exercising, stress, sleep deprivation | sleep | I | 1 | 14 | 2 | 2 | none |
| 13/43/F/C |
M694V (+/−) MEFV gene (exon 10) |
hands, legs, abdominal, chest | pulsatile, stabbing, dragging, burning | 7 | stress | sleep | IV | 3 | 21 | 19 | 16 | ibuprofen |
| 14/39/M/C |
V726A (+/−) MEFV gene (exon 10) |
abdominal | dull, pulsatile, stabbing, dragging, burning | 12 | n.k. | no influenceable factors are known | IV | 3 | 12 | 11 | 7 |
tramadol, tilidine, oxycodone, etoricoxib |
| 15/33/F/C |
I591T (+/−) MEFV gene (exon 9) |
head, cervical, thoracic, lower back, shoulder, arms, hands, pelvic area, legs, feet, abdominal, chest | dull, dragging, burning | 7 | over-exercising, stress | meditation, reading, take a walk, meeting friends | IV | 2 | 40 | 3 | 5 | none |
| 16/55/F/C | M680I (+/−) MEFV gene (exon 10) | thoracic, shoulder, arms, hands, pelvic area, legs, feet | dull, stabbing, dragging | 9 | stress | exercise, psychotherapy | IV | 2 | 45 | 9 | 12 | none |
| 17/32/F/C | R92Q (+/−) TNFRSF1A gene (exon 4) | head, cervical, shoulder, arms, legs | dull, pulsatile, stabbing, dragging | 5 | fatigue, stress | take a walk, sleep | III | 0 | 42 | 6 | 8 | ibuprofen |
| 18/55/F/C | R92Q (+/+) TNFRSF1A gene (exon 4) | hands, feet, abdominal | dull, stabbing, dragging | 4 | warmness | take a walk, breathing exercises, distraction | II | 1 | 0 | 9 | 9 | none |
| 19/43/F/C | R92Q (+/−) TNFRSF1A gene (exon 4) | thoracic, lower back, arms, hands, legs, feet abdominal | dull, stabbing, dragging, burning | 2 | n.k. | tranquility, relaxation, medications | III | 2 | 0 | 7 | 0 | none |
| 20/31/F/C | R92Q (+/−) TNFRSF1A gene (exon 4) | thoracic, arms, hands, pelvic area, legs, feet, abdominal | stabbing, dragging | 6 | weather changes, food intake, mental stress | distraction, meditation, exercise | IV | 2 | 25 | 5 | 5 | steroids |
| 21/56/F/C | R92Q (+/−) TNFRSF1A gene (exon 4) | legs | stabbing, pruritic | 1 | warmness, alcohol, period, stress | cold, fresh air, sleep, relaxation, distraction | I | 1 | 0 | 7 | 5 | morphin, tramadol, pregabaline |
f female, m male, C Caucasian