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. 2020 Dec 17;10:22192. doi: 10.1038/s41598-020-79114-3

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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A representative histologic appearance of EVPOMEs manufactured for a total 11 of days, 4 days in a submerged, and subsequent 7 days in an air–liquid interface condition. (n = 5): Hematoxylin and eosin staining (original magnifications 20 ×) A continuous and well-stratified epithelial layer that resembles to “rete ridges” was formed. (a–g) indicate micropatterned collagen scaffolds originally designed by sample IDs of 9, 10, 11, 12, 13, 14, and 15 shown in Fig. 1, respectively.