Figure 3.

Coinfusion of recombinant BDNF reverses the effect of RAPA on fear-motivated avoidance extinction memory reconsolidation. Animals were trained in SDIA (TR; 0.4 mA/2 sec) and beginning 24 h later were submitted to one daily extinction session for five consecutive days (EXT). Twenty-four hours after the last session, extinction memory was reactivated (RA) and 5 min later the animals received bilateral intradorsal CA1 infusions of vehicle (VEH; 5% DMSO in saline), rapamycin (RAPA; 0.02 µg/side), BDNF (0.25 µg/µL), or RAPA plus BDNF (RAPA + BDNF). Retention was assessed 1 and 7 d later (Test). Data expressed as median ± IQR. (***) P < 0.001 versus VEH in Dunn's multiple comparisons after Kruskal–Wallis test.