Table IV.
Spearman rank correlation analysis of MT, Ki-67 expression and selected histologic parameters in 34 liver samples with histologic diagnosis of cholangiohepatitis.
| Variable | MT-positive cells in 0.625 mm2 | MT labelling intensity | Ki-67 positive cells 0.625 mm2 | |||
|---|---|---|---|---|---|---|
|
|
|
|
||||
| P-value | r | P-value | r | P-value | r | |
| Inflammationa | 0.03* | 0.366 | 0.03* | 0.370 | 0.20 | −0.225 |
| Fibrosisb | 0.66 | 0.078 | 0.70 | 0.070 | 0.87 | −0.028 |
| BDPc | 0.23 | 0.211 | 0.92 | −0.016 | 0.90 | −0.021 |
| Ki-67d | 0.95 | 0.011 | 0.65 | 0.079 | — | — |
MT — Metallothionein; BDP — Bile duct proliferation.
a
Mean number of inflammatory cells surrounding 5 random portal areas.
b
Mean fibrosis score by 2 independent pathologists examining 5 random HPF (40×).
c
Mean number of bile ducts counted in 5 random portal areas by 2 independent pathologists.
d
Mean number of hepatocytes with positive Ki-67 staining in 10 random HPF (40×).
*
Statistically significant.