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. 2020 Dec 17;11:6409. doi: 10.1038/s41467-020-20262-5

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — a Domain architecture of RPC5 C terminus. tWHD1 and tWHD2 are coloured in red and green shades, respectively. Regions are depicted according to their presence (black line) or absence (black dashed line) in the crystal structures. DM refers to RPC5 dimerization module. b Crystallographic model of RPC5-WHD1 (dark red), RPC5-WHD2 (light red) and the linker regions (grey) in ribbon cartoon. Inset shows detail of the electron density map. c Overall structure of RPC5-tWHD2 crystallographic packing in ribbon cartoon. RPC5-WHD3 and RPC5-WHD4 are shown in dark and light green, respectively, and the inset shows detail of the electron density map. d Fitting of RPC5-tWHD1 (red, inset) into the SAXS experimental data (black). e Fitting of RPC5-tWHD2 in ‘closed’ (green, inset), ‘open’ (dashed green) and dimer (orange) conformations into the SAXS experimental data (black). f Docking of RPC5-tWHD1 (red) and RPC5-tWHD2 (green) into the ab initio SAXS envelope generated from RPC5EXT SAXS data collection.