Table 1.
Quantitative magnetic resonance imaging (MRI) techniques.
| MRI Technique | Pancreas Pathology Interrogated | Change in T1D | Change in T2D | Biological Confounders | Technical Confounders |
|---|---|---|---|---|---|
| Anatomical MRI | Pancreas Volume | ↓↓ | ↓ | Age; weight | |
| Fat Fraction Mapping | Fat infiltration | ↔ | ↑ | Age, sex, visceral adiposity | MRI acquisition; pancreas heterogeneity |
| Longitudinal Relaxation (T1) | Fibrosis | ? | ? | Age | MRI acquisition; magnetic field strength; pancreas heterogeneity |
| Extracellular Volume Fraction (ECV) | Fibrosis | ? | ↑ | MRI acquisition; contrast agent administration; magnetic field strength; pancreas heterogeneity | |
| Diffusion-Weighted Imaging (DWI) | Cell density; membrane integrity; fibrosis | ↑ | ? | Age, sex | MRI acquisition; magnetic field strength; pancreas heterogeneity |
| Dynamic Contrast-Enhanced (DCE) | Perfusion; vascular permeability | ? | ↑ | MRI acquisition; contrast agent administration; processing technique; pancreas heterogeneity | |
| Arterial Spin Labeling (ASL) | Perfusion | ? | ? | MRI acquisition; pancreas heterogeneity | |
| Incoherent Intravoxel Motion (IVIM) | Microvascular perfusion | ? | ? | MRI acquisition; processing technique | |
| Blood Oxygen Level Dependent (BOLD) | Perfusion; oxygen consumption | ? | ? | ||
| Magnetic Resonance Elastography (MRE) | Stiffness; fibrosis | ? | ↑ | Age | MRI acquisition; processing technique |
↑ = increase; ↓ == decrease; ↔ = no change; ? = unknown.