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. 2020 Dec 4;11:585984. doi: 10.3389/fphar.2020.585984

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Copyright © 2020 Ruan, Jin, Zeng, Ren, Xie, Ji, Wu, Wu and Li

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Inhibition of PI3K/AKT pathway can reverse the anti-apoptosis and anti-fibrosis effects of GSPE. (A) Effects of GSPE treatment on cardiac levels of p-PI3K, PI3K, p-AKT evaluated by Western blot analysis. (B) Effects of GSPE on the levels of Bax and Bcl-2 evaluated by Western blot analysis. (C) Effects of GSPE on the levels of Col-1, Col-3 and a-SMA evaluated by Western blot analysis. (D) Immunofluorescence staining of a SMS. *Significant difference comapred with the MI froup, p < 0.05; significant difference compared with the MI + GSPE group, p < 0.05. n = 3 per group.