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. Author manuscript; available in PMC: 2021 Jan 1.
Published in final edited form as: Nat Chem Biol. 2020 May 11;16(7):783–790. doi: 10.1038/s41589-020-0544-7

Fig. 3 |. The AKBA- and NDGA- binding sites in 5-LOX.

Fig. 3 |

a, AKBA (stick; C, yellow and O, red) binds lengthwise in an interdomain crevice of 5-LOX, and while not fully encapsulated makes multiple hydrophobic and polar contacts along the interface and is poised to affect interdomain flexibility. b, The cavity of 5-LOX that houses NDGA (stick; C, pink and O red) is open to solvent and does not effectively envelop the inhibitor.