TABLE 3.

Overall Quality of Evidence for Outcomes (Modified GRADE)⁵⁴

Outcome	Summary RoB assessmenta	Indirectness	Imprecision	Inconsistency	Publication bias	Magnitude of effect	Confounder effectb	Overall
SGTP vs GT switch43,47,49,51	Unclear	Direct	Precise	Consistent	No	Large	No	Moderate
High-grade CIN; SGTP vs GT switch47,49–51	Low	Direct	Precise	Consistent	No	Large	No	High
Genotype risk discrimination; high-grade CIN; SGTP2,42,43,48,50–53	Unclear	Direct	Precise	Consistent	No	Moderate	No	Moderate

^aSee RoB table (see Table 2).

^bCofounder effect characterizes the degree to which all plausible confounders would tend to increase confidence in the estimated effect.