Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2020 Nov 9;13(6):e002911. doi: 10.1161/CIRCGEN.120.002911

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2020 The Authors.

Circulation: Genomic and Precision Medicine is published on behalf of the American Heart Association, Inc., by Wolters Kluwer Health, Inc. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution, and reproduction in any medium, provided that the original work is properly cited.

PMC Copyright notice

Figure 3. — Cumulative number of risk alleles at the 3 loci and the associated likelihood of Brugada Syndrome (BrS) phenotype showing performance of the BrS-genetic risk score for prediction of BrS phenotype in mutation positive individuals.A, Total cohort; (B) individuals harboring E1784K-SCN5A; (C) individuals harboring loss-of-function SCN5A mutations causing haploinsufficiency; (D) individuals harboring other missense SCN5A mutations. Distribution of numbers of risk alleles hosted by individuals with BrS phenotype (black bars) in each cohort are shown vs family members ascertained to be BrS phenotype-negative (white bars). Each bar represents the proportion of individuals carrying the corresponding number of risk alleles as a percentage of the total number of individuals with the corresponding phenotype, that is, denominator for the white bars being the total number of individuals with no BrS within the cohort, and the denominator for the black bars being the total number of individuals with BrS within the cohort.