TABLE 1.

Spectrum of Architecture in dVIN and VAM²⁰

Diagnosis	Epithelial thickness	Rete ridges—size	Rete ridges—shape	Stroma	Lymphocytic infiltrate
Nonkeratinizing dVIN
Basaloid dVIN	Normal to thick 0.1–0.5 mm	Reduced	Flat acanthosis Blunted or bulbous	Normal Fibrosis and/or sclerosis	Moderate to dense
Intermediate dVIN	Normal to thick 0.08–0.6 mm	Reduced to enlarged	Flat acanthosis Blunted or bulbous	Normal Fibrosis and/or sclerosis	Variable
Keratinizing dVIN
Atrophic	Thin <0.2 mm	Reduced	N/A	Sclerosis and/or fibrosis Normal	Variable
Subtle	Normal 0.18–0.35 mm	Reduced to normal	Normal	Sclerosis and/or fibrosis Normal	Scant to moderate
Traditional	Normal to thick 0.1–0.9 mm	Enlarged	Branched Clubbed	Sclerosis and/or fibrosis Normal	Variable
Acantholytic	Normal to thick 0.14–1.5 mm	Enlarged	Branched Clubbed	Sclerosis and/or fibrosis Normal	Variable
Hypertrophic	Markedly thick 0.6–2.2	Enlarged	Branched Complex	Fibrosis and/or sclerosis	Moderate to dense
VAM	Thick 0.35–2.5	Reduced to enlarged	Flat acanthosis Branched	Sclerosis and/or fibrosis Normal	Scant to moderate