Table 4.

Univariate and multivariate logistic regression analyses of variables associated with advanced fibrosis (F>2) and cirrhosis (F>3) and C-statistics

Variable	Univariate		C-statistics	Model 1*		C-statistics	Model 2†		C-statistics
				Multivariate			Multivariate
	Odds ratio (95% CI)	P		Odds ratio (95% CI)	P		Odds ratio (95% CI)	P
F>2						0.95 (0.90–0.99)			0.94 (0.90–0.98)
M2BPGi	9.572 (3.668–24.978)	< 0.001	0.87 (0.80–0.93)	4.949 (1.424–17.196)	0.012		5.187 (1.648–16.328)	0.005
APRI	3.500 (1.711–7.161)	0.001	0.76 (0.68–0.84)	0.658 (0.160–2.713)	0.563
FIB-4	4.043 (2.405–6.797)	< 0.001	0.92 (0.87–0.97)	1.981 (0.677–5.795)	0.212
NFS	3.860 (2.291–6.502)	< 0.001	0.92 (0.87–0.97)	2.089 (0.905–4.819)	0.084		3.376 (1.941–5.870)	< 0.001
F>3						0.95 (0.91–0.99)			0.94 (0.90–0.98)
M2BPGi	5.818 (2.368–14.297)	< 0.001	0.90 (0.84–0.96)	3.605 (1.111–11.701)	0.033		3.244 (1.126–9.345)	0.033
APRI	1.270 (0.681–2.370)	0.453	0.64 (0.55–0.73)	0.054 (0.002–1.240)	0.068
FIB-4	1.787 (1.344–2.377)	< 0.001	0.89 (0.84–0.95)	1.771 (0.821–3.822)	0.145
NFS	3.114 (1.805–5.370)	< 0.001	0.93 (0.88–0.97)	2.337 (0.999–5.467)	0.050		2.533 (1.451–4.423)	0.050

^*Model 1 used M2BPGi, APRI, FIB-4, and NFS as independent variables; †Model 2 selected significant variables by a stepwise method using M2BPGi, APRI, FIB-4, and NFS as independent variables.

Abbreviations: APRI, aspartate aminotransferase to platelet ratio index; CI, confidence interval; F, fibrosis; FIB-4, fibrosis index based on four factors; M2BPGi, Mac-2 binding protein glycosylation isomer; NAFLD, non-alcoholic fatty liver disease; NFS, NAFLD fibrosis score.