Table 3.
Analysis of the association between ABCB1 SNPs and CML risk
| SNP/model | Genotype |
Controls
n = 100 (%) |
Patients
n = 98 (%) |
p
*
value |
OR
*
(95% CI) |
|
|---|---|---|---|---|---|---|
| c.1236C>T | Codominant | TT | 29 (29.0) | 25 (25.5) | Ref | 1 |
| CT | 53(53.0) | 54 (55.1) | 0.88 | 1.08 (0.53-2.20) | ||
| CC | 18(18.0) | 19(19.4) | 0.88 (0.35-2.21) | |||
| Dominant | TT | 29 (29.0) | 25 (25.5) | Ref | 1 | |
| CT/CC | 71 (71.0) | 73 (74.5) | 0.93 | 1.03 (0.52-2.03) | ||
| Recessive | TT/CC | 82 (82.0) | 79 (80.6) | Ref | 1 | |
| CT | 18 (18.0) | 19 (19.4) | 0.65 | 0.83 (0.38-1.84) | ||
| Alleles | T | 111 (51.6) | 104 (48.4) | Ref | 1 | |
| C | 89 (49.2) | 92 (50.8) | 0.85 | 0.96 (0.62-1.476) | ||
| c.3435C>T | Codominant | TT | 29 (29.0) | 22 (22.4) | Ref | 1 |
| CT | 49 (49.0) | 57 (58.2) | 0.66 | 1.13 (0.54-2.33) | ||
| CC | 22 (22.0) | 19 (19.4) | 0.78 (0.31-1.94) | |||
| Dominant | TT | 29 (29.0) | 22 (22.4) | vef | 1 | |
| CT/CC | 71 (71.0) | 76 (77.5) | 0.95 | 1.02 (0.51-2.05) | ||
| Recessive | TT/CT | 78 (78.0) | 79 (80.6) | Ref | 1 | |
| CC | 22 (22.0) | 19 (19.4) | 0.4 | 0.72 (0.34-1.55) | ||
| Alleles | T | 107 (51.4) | 101 (48.6) | Ref | 1 | |
| C | 93 (49.5) | 95 (50.5) | 0.66 | 0.9 (0.59-104) |
Ref, reference; *logistic regression model adjusted for sex, age, and smoking status