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. 2020 Dec 8;16(12):e1009101. doi: 10.1371/journal.ppat.1009101

Fig 2. B cell priming in vaccine recipients altered subclass and antibody specificity to HIV-1 following infection.

Fig 2

(A) IgG1, (B) IgG2, (C) IgG3, and (D) IgG4 subclass binding to HIV-1 Env antigens at 6 months (N = 24 vaccine, 31 placebo), one year (N = 18 vaccine, 39 placebo), and three years (N = 27 vaccine, 49 placebo) post-HIV-1 diagnosis. The fold over background is represented for each Env antigen as a composite score corresponding to the geometric mean of the fold over background across the different antigens tested: 9 gp120s, 23 gp140s, 6 V1V2 gp70 and 4 V3 gp70 antigen. P values were calculated by Mann-Whitney U test and adjusted by False Discovery Rate (FDR) for multiple comparisons. Only significant (p<0.05) p values are shown.