Fig 3. Predictions of the effect of combination treatment targeting both TMPRSS2 and Cathepsin B/L pathways.

(A) The fraction of infection events unaffected by Cathepsin B/L inhibitor, TMPRSS2 inhibitor or both for different drug concentrations. The extent of predicted horizontal and vertical or Bliss synergy (see text) are marked. (B, C) The expected effect of the combination from Bliss independence (B) and predicted combination effect (C) over varying drug concentrations. (D) The predicted Bliss synergy over a range of drug concentrations. The parameters and initial conditions are listed in S1 Table.