Table 4. Factors associated with in-hospital death.
| Variables | Non-survivor (n = 33) | Survivor (127) | Univariate OR | p value | Multivariate OR | P value | |
|---|---|---|---|---|---|---|---|
| Age_years | 59 (51–69) | 52 (36–62) | 1.04 (1.01–1.07) | 0.006* | 1.06 (1.0–1.11) | 0.033* | |
| Sex | Male | 17 (53%) | 66 (52%) | 1.06 (0.49–2.32) | 0.881 | - | - |
| Female | 16 (47%) | 61 (48%) | 1 | ||||
| Presence of Comorbidity | Yes | 23 (69%) | 53 (42%) | 3.06 (1.34–7.02) | 0.008* | - | - |
| No | 10 (31%) | 74 (58%) | 1 | ||||
| Hypertension | Yes | 15 (44%) | 42 (33%) | 1.59 (0.72–3.53) | 0.249 | - | - |
| No | 18 (56%) | 85 (67%) | 1 | ||||
| Diabetes | Yes | 9 (28%) | 22 (17%) | 1.88 (0.76–4.65) | 0.168 | - | - |
| No | 24 (72%) | 105 (83%) | 1 | ||||
| Obesity | Yes | 3 (9%) | 9 (7%) | 1.30 (0.33–5.11) | 0.708 | - | |
| No | 30 (91%) | 118 (93%) | 1 | ||||
| Heart disease | Yes | 4 (12%) | 8 (6%) | 2.35 (0.64–8.58) | 0.197 | - | - |
| No | 29 (88%) | 119 (94%) | 1 | ||||
| Respiratory rate_breaths/ min | ≤24 | 8 (24%) | 98 (77%) | 10.71 (4.04–28.36) | <0.0001* | - | - |
| >24 | 25 (76%) | 29 (23%) | 1 | ||||
| SpO2_%, median (IQR) | 81 (62–87) | 97 (91–99) | 0.92 (0.89–0.96) | <0.0001* | 0.94 (0.90–0.98) | 0.007* | |
| Fever | Yes | 26 (78%) | 67 (53%) | 3.13 (1.26–7.78) | 0.014* | - | - |
| No | 7 (22%) | 60 (47%) | 1 | ||||
| Cough | Yes | 22 (67%) | 70 (55%) | 1.96 (0.83–4.58) | 0.12 | - | - |
| No | 11 (33%) | 57 (45%) | 1 | ||||
| qSOFA | 1.0 (1.0–2.0) | 1.0 (0.0–1.0) | 5.11 (2.21–11.85) | 0.0001* | 4.02 (0.84–19.22) | 0.081 | |
| SIRS | Yes | 32 (96%) | 77 (61%) | 15.57 (2.03–119.27) | 0.008* | - | - |
| No | 1 (4%) | 50 (39%) | 1 | ||||
| Shortness of breath | Yes | 27 (81%) | 48 (38%) | 7.15 (2.74–18.68) | 0.0001* | - | - |
| No | 6 (19%) | 79 (62%) | 1 | ||||
| Hydroxychloroquine (or Chloroquine phosphate)- Azithromycin | Yes | 25 (75%) | 122 (96%) | 0.13 (0.04–0.43) | 0.0008* | 0.24 (0.03–2.2) | 0.208 |
| No | (25%) | 5 (4%) | 1 | ||||
| Therapeutic itinerary | Attended directly Cl.Ng. | 19 (58%) | 97 (76%) | 2.24 (0.98–5.13) | 0.056 | - | - |
| Transferred from non-CTC | 14 (42%) | 30 (24%) | 1 | ||||
| Heart rate_beats /min | 111 (98–119) | 88 (82–99) | 1.07 (1.04–1.11) | <0.0001* | 1.06 (1.02–1.11) | 0.027* | |
| WBC counts_cells/μL, median (IQR) | 8700 (6300–13300) | 5800 (4500–8400) | 1 (1–1) | 0.105 | - | - | |
| Neutrophils_%, median (IQR) | 75 (69–85) | 62 (50–75) | 1.05 (1.02–1.09) | 0.004* | - | - | |
| Lymphocytes_%, median (IQR) | 21 (15–28) | 31 (19–42) | 0.96 (0.93–0.99) | 0.024* | |||
| PCT_ μg/L, median (IQR) | <0.5 | 3 (8%) | 41 (32%) | 1 | |||
| ≥0.5 | 30 (92%) | 86 (68%) | 5.18 (1.16–23.26) | 0.032* | - | - | |
| CRP_ mg/L, median (IQR) | 148 (27–319) | 42 (0.5–96) | 1.01 (1–1.01) | 0.0002* | - | - | |
| D-dimer_ mg/L | <1000 | 3 (8%) | 47 (37%) | 1 | |||
| ≥1000 | 30 (92%) | 80 (63%) | 6.33 (1.41–28.42) | 0.016* | - | - | |
| ALT_UI/L | 32 (15–59) | 55 (29–77) | 1.01 (0.99–1.02) | 0.062 | - | - | |
| AST_ UI/L | 22 (60–102) | 83 (128–159) | 1.02 (1.01–1.03) | <0.0001* | 1.02 (1.01–1.03) | 0.005* | |
| Urea_ mg/dL | 35 (20–73) | 24 (17–42) | 1.01 (1–1.03) | 0.015* | |||
| Creatinine_ mg/dL | ≤15 | 26 (79%) | 119 (94%) | 1 | |||
| >15 | 7 (21%) | 8 (6%) | 3.95 (1.14–13.75) | 0.031* | - | - | |
Data are n (%) or median (IQR), %: Proportion, ALT: Alanine aminotransferase, AST: Aspartate aminotransferase, CRP: C-reactive protein, PCT: Procalcitonin, SpO2: Peripheral oxygen saturation, qSOFA = Quick Sequential Organ Failure Assessment, SIRS: Systemic Inflammatory Response Syndrome, OR: Odds ratio.