Table 2.

Occupational physical activity and incident stroke (N=441). Hazard ratios (HR) and 95% confidence intervals (CI) from Cox regression analyses with incremental adjustment for potential confounders. Sister Study, 2004–2015, N=31 270.

Occupational physical activity	N Case/Exposed	Model 1a		Model 2 b		Model 3 c		Model 4 d
		HR	95% CI	HR	95% CI	HR	95% CI	HR	95% CI
Current job
Mostly sitting	221/16287	1.00		1.00		1.00		1.00
Sitting and standing equally	103/6386	1.15	0.91–1.45	1.18	0.93–1.49	1.19	0.94–1.51	1.18	0.93–1.49
Mostly standing	67/4656	1.03	0.78–1.35	1.04	0.79–1.36	1.06	0.80–1.39	1.05	0.80–1.39
High intensity work	40/2477	1.24	0.88–1.73	1.12	0.80–1.56	1.11	0.79–1.56	1.11	0.79–1.56
Continuous walking/movements	35/2225	1.20	0.84–1.72	1.10	0.77–1.57	1.10	0.77–1.57	1.10	0.77–1.57
Heavy manual labor	5/252	1.52	0.63–3.68	1.27	0.52–3.08	1.24	0.51–3.02	1.21	0.50–2.95
Longest held job
Mostly sitting	194/14444	1.00		1.00		1.00		1.00
Sitting and standing equally	94/6586	1.01	0.79–1.29	1.03	0.80–1.32	1.03	0.80–1.32	1.02	0.80–1.31
Mostly standing	80/5549	1.05	0.81–1.36	1.03	0.79–1.34	1.04	0.80–1.35	1.04	0.80–1.35
High intensity work	63/3227	1.56	1.17–2.07	1.46	1.09–1.94	1.45	1.08–1.94	1.44	1.08–1.93
Continuous walking/movements	58/2821	1.62	1.21–2.18	1.54	1.15–2.07	1.53	1.14–2.07	1.53	1.13–2.06
Heavy manual labor	5/406	1.04	0.43–2.53	0.88	0.36–2.15	0.89	0.36–2.16	0.87	0.36–2.13

^aModel 1 adjusts for age.

^bModel 2 adjusts for age, leisure-time physical activity, alcohol, smoking, and body mass index.

^cModel 3 adjusts for age, leisure-time physical activity, alcohol, smoking, body mass index, discrimination at work, and night work.

^dModel 4 adjusts for age, leisure-time physical activity, alcohol, smoking, body mass index, discrimination at work, night work, and rate pressure product.