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. Author manuscript; available in PMC: 2020 Dec 18.
Published in final edited form as: J Pathol. 2020 May 18;251(3):284–296. doi: 10.1002/path.5451

Figure 1.

Figure 1.

Loss of Trp73 extended life span and decreased tumor formation in Fdxr+/− mice. (A) Kaplan-Meier survival curve for WT (n = 56), Trp73+/− (n = 26), Fdxr+/− (n = 31) and Fdxr+/−;Trp73+/− (n = 24) mice. The median lifespan was 117 weeks for WT mice, 82 weeks for Trp73+/− mice, 102 weeks for Fdxr+/− mice and 104 weeks for Fdxr+/−;Trp73+/−. (B) The numbers and percentages of WT, Trp73+/−, Fdxr+/− and Fdxr+/−;Trp73+/− mice with liver steatosis. (C) The numbers and percentages of WT, Trp73+/−, Fdxr+/− and Fdxr+/−;Trp73+/− mice with systemic inflammation. (D) The numbers and percentages of WT, Trp73+/−, Fdxr+/− and Fdxr+/−;Trp73+/− mice with splenic or thymic hyperplasia.