Table 3.
The differentially expressed genes that encoded the receptors binding to adsorbed proteins involved in the ECM-receptor interaction pathway
| Types of genes | Gene symbol | Chitosan film | Collagen/chitosan film |
|---|---|---|---|
| Integrin genes | Itga2b | 3.274 ± 0.228↑ | |
| Itga3 | 0.183 ± 0.000↓ | ||
| Itga4 | 0.178 ± 0.000↓ | ||
| Itga5 | 0.074 ± 0.019↓ | ||
| Itga6 | 0.257 ± 0.007↓ | ||
| Itga8 | 4.594 ± 0.010↑ | 3.558 ± 0.013↑ | |
| Itgb1 | 0.011 ± 0.000↓ | 0.199 ± 0.001↓** | |
| Itgb5 | 0.021 ± 0.014↓ | ||
| Itgb6 | 2.094 ± 0.054↑ | ||
| Itgb8 | 2.024 ± 0.037↑ | ||
| Proteoglycan-encoding genes | Cd44 | 2.234 ± 0.550↑ | |
| Sdc1 | 2.046 ± 0.010↑ | ||
| Sdc4 | 6.220 ± 1.867↑ | 3.065 ± 0.010↑** | |
| Glycoprotein-encoding genes | RGD1565355 | 7.887 ± 0.077↑ | |
| Immunoglobulin genes | Cd47 | 0.031 ± 0.000↓ | 2.156 ± 0.030↑** |
| Number of up-regulated genesa | 6 | 5 | |
| Number of down-regulated genesb | 6 | 2 |
a
Up-regulated genes (expression value > 2).
b
Down-regulated genes (expression value < 0.5).
**
P < 0.01, fold change of one gene between chitosan and collagen/chitosan groups was considered to have a very significant difference.