Table 2.
Clusters showing significant differences across BD, SZ, and HC groups with one-way ANCOVA.
| Cluster | Brain regions | Voxels | Peak MNI coordinate | F | p | Post hoc analysis | ||
|---|---|---|---|---|---|---|---|---|
| x | y | z | ||||||
| A | R-dorsolateral superior frontal gyrus | 1638 | 24 | 49.5 | 28.5 | 11.629 | <0.001∗ | SZ<HC (p < 0.001∗) BD < HC (P = 0.022∗) SZ vs BD (p = 0.336) |
| B | L-orbital middle frontal gyrus L-middle frontal gyrus L-orbital superior frontal gyrus |
1444 | -28.5 | 60 | -2.84 | 12.008 | <0.001∗ | SZ<HC (p < 0.001∗) BD<HC (p = 0.036∗) SZ vs. BD (p = 0.191) |
| C | L-rectus R-rectus |
1420 | -7.5 | 36 | -21 | 11.090 | <0.001∗ | SZ<HC (p < 0.001∗) BD<HC (p = 0.03∗) SZ vs. BD (p = 1.000) |
| D | R-insula R-temporal pole-superior temporal gyrus R-amygdala |
1319 | 34.5 | 7.5 | -19.5 | 13.476 | <0.001∗ | SZ<HC (p < 0.001∗) BD<HC (p = 0.010∗) SZ vs. BD (p = 0.298) |
| E | L-superior temporal gyrus | 943 | -61.5 | -58.5 | 15 | 15.155 | <0.001∗ | SZ<HC (p < 0.001∗) BD vs. HC (p = 0.243) SZ<BD (p = 0.006∗) |
| F | L-insula | 906 | -33 | 7.5 | 19.5 | 12.144 | <0.001∗ | SZ<HC (p < 0.001∗) BD<HC (p = 0.017∗) SZ vs. BD (p = 0.341) |
| G | L-dorsolateral superior frontal gyrus L-middle frontal gyrus L-anterior cingulate and paracingulate gyri |
856 | -19.5 | 58.5 | 25.5 | 15.475 | <0.001∗ | SZ<HC (p < 0.001∗) BD<HC (p = 0.006∗) SZ vs. BD (p = 0.196) |
| H | L-insula L-opercular inferior frontal gyrus L-temporal pole-superior temporal gyrus |
811 | -48 | 16.5 | 1.5 | 14.456 | <0.001∗ | SZ < HC (P < 0.001∗) BD < HC (P = 0.004∗) SZ vs BD (p = 0.421) |
| I | R-medial superior frontal gyrus | 797 | 3 | 60 | -1.5 | 10.622 | <0.001∗ | SZ<HC (p < 0.001∗) BD<HC (p = 0.007∗) SZ vs. BD (p = 1.000) |
| J | R-supramarginal gyrus | 565 | 64.5 | -16.5 | 28.5 | 11.030 | <0.001∗ | SZ<HC (p < 0.001∗) BD vs. HC (p = 1.000) SZ<BD (p = 0.004∗) |
GRF, Gaussian random field corrections; MNI, Montreal Neurological Institute; L, left; R, right; x, y, z, coordinates of peak voxel. ∗Significant at p < 0.05. Post hoc analysis is the Bonferroni correction.