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. Author manuscript; available in PMC: 2021 Jan 1.
Published in final edited form as: Trends Cell Biol. 2020 Nov 9;31(1):50–61. doi: 10.1016/j.tcb.2020.10.004

Figure I. Severing-Dependent Microtubule Disassembly.

Figure I.

(A,B) Overexpression of spastin in a rat fibroblast fragments the microtubules. Bar, 10 μm. Adapted from [54]. (C) Model scheme of microtubule loss due to severing. The newly created plus end without a GTP cap rapidly depolymerizes. Under low- or no-rescue conditions, severing eventually leads to a decrease of microtubule length, number, and mass.