Table 2.
Sociodemographic and clinical characteristics of controls without Barrett’s esophagus (BE) versus cases with BE, asymptomatic controls versus asymptomatic BE cases, and asymptomatic BE cases versus symptomatic BE cases recruited from a primary care population.
| All controls N=469 |
All cases N=44 |
P value | Asymptomatic controls N=346 |
Asymptomatic cases N=25 |
P value | Asymptomatic cases N=25 |
Symptomatic cases N=19 |
P value | |
|---|---|---|---|---|---|---|---|---|---|
| Age, mean (SD, years) | 61.6 (6.7) | 60.7 (5.5) | 0.192 | 61.9 (6.8) | 60.7 (6.1) | 0.193 | 60.7 (6.1) | 60.6 (4.7) | 0.479 |
| Stratified age | |||||||||
| <60 years | 169 (36.0%) | 14 (31.8%) | 0.577 | 120 (34.7%) | 8 (32.0%) | 0.785 | 8 (32.0%) | 6 (31.6%) | 0.976 |
| ≥60 years | 300 (64.0%) | 30 (68.2%) | 226 (65.3%) | 17 (68.0%) | 17 (68.0%) | 13 (68.4%) | |||
| Sex | |||||||||
| Male | 452 (96.4%) | 44 (100.0%) | 0.199 | 339 (98.0%) | 25 (100.0%) | 0.473 | 25 (100.0%) | 19 (100.0%) | 1.000 |
| Female | 17 (3.6%) | 0 (0.0%) | 7 (2.0%) | 0 (0.0%) | 0 (0.0%) | 0 (0.0%) | |||
| Race | |||||||||
| Non-Hispanic White | 216 (46.1%) | 30 (68.2%) | 0.004 | 153 (44.2%) | 18 (72.0%) | 0.009 | 18 (72.0%) | 12 (63.2%) | 0.712 |
| African-American | 202 (43.1%) | 7 (15.9%) | 156 (45.1%) | 3 (12.0%) | 3 (12.0%) | 4 (21.1%) | |||
| Hispanic | 45 (9.6%) | 7 (15.9%) | 31 (9.0%) | 4 (16.0%) | 4 (16.0%) | 3 (15.8%) | |||
| Other | 6 (1.3%) | 0 (0.0%) | 6 (1.7%) | 0 (0.0%) | 0 (0.0%) | 0 (0.0%) | |||
| GERD presence/duration | |||||||||
| None | 346 (73.8%) | 25 (56.8%) | 0.025 | --- | --- | --- | --- | --- | --- |
| <5 years | 3 (0.6%) | 1 (2.3%) | --- | --- | --- | --- | |||
| ≥5 years | 120 (25.6%) | 18 (40.9%) | |||||||
| Smoking Status | |||||||||
| Never smoker | 119 (25.4%) | 10 (22.7%) | 0.832 | 93 (26.9%) | 5 (20.0%) | 0.705 | 5 (20.0%) | 5 (26.3%) | 0.765 |
| Former smoker | 226 (48.2%) | 20 (45.5%) | 162 (46.8%) | 11 (44.0%) | 11 (44.0%) | 9 (47.4%) | |||
| Current smoker | 122 (26.0%) | 14 (31.8%) | 90 (26.0%) | 9 (36.0%) | 9 (36.0%) | 5 (26.3%) | |||
| Missing | 2 (0.4%) | 0 (0.0%) | 1 (0.3%) | 0 (0.0%) | 0 (0.0%) | 0 (0.0%) | |||
| Alcohol drinking status | |||||||||
| Never Drinker | 29 (6.2%) | 1 (2.3%) | 0.691 | 23 (6.7%) | 0 (0.0%) | 0.385 | 0 (0.0%) | 1 (5.3%) | 0.275 |
| Former Drinker | 168 (36.1%) | 15 (34.1%) | 123 (35.9%) | 7 (28.0%) | 7 (28.0%) | 8 (42.1%) | |||
| Current Drinker | 268 (57.5%) | 28 (63.6%) | 196 (57.1%) | 18 (72.0%) | 18 (72.0%) | 10 (52.6%) | |||
| Missing | 1 (0.2%) | 0 (0.0%) | 1 (0.3%) | 0 (0.0%) | 0 (0.0%) | 0 (0.0%) | |||
| Waist-to-hip ratio | |||||||||
| 1st Tertile | 170 (36.8%) | 88 (18.2%) | 0.034 | 122 (35.9%) | 5 (20.0%) | 0.262 | 10 (40.0%) | 9 (47.4%) | 0.344 |
| 2nd Tertile | 157 (34.0%) | 17 (38.6%) | 116 (34.1%) | 10 (40.0%) | 9 (36.0%) | 3 (15.8%) | |||
| 3rd Tertile | 135 (29.2%) | 19 (43.2%) | 102 (30.0%) | 10 (40.0%) | 6 (24.0%) | 7 (36.8%) | |||
| BMI | |||||||||
| Normal | 73 (15.6%) | 5 (11.4%) | 0.702 | 60 (17.3%) | 2 (8.0%) | 0.376 | 2 (8.0%) | 3 (15.8%) | 0.617 |
| Overweight | 165 (35.2%) | 24 (54.6%) | 120 (34.7%) | 8 (32.0%) | 8 (32.0%) | 9 (47.4%) | |||
| Obese | 231 (49.3%) | 15 (34.1%) | 166 (48.0%) | 15 (60.0%) | 15 (60.0%) | 7 (36.8%) | |||
| H. pylori infection | |||||||||
| No | 297 (63.3%) | 28 (63.6%) | 0.967 | 211 (61.0%) | 14 (56.0%) | 0.622 | 14 (56.0%) | 14 (73.7%) | 0.227 |
| Yes | 172 (36.7%) | 16 (36.4%) | 135 (39.0%) | 11 (44.0%) | 11 (44.0%) | 5 (26.3%) | |||
| PPI or H2RA use | |||||||||
| No | 338 (72.5%) | 25 (56.8%) | 0.028 | 292 (84.9%) | 18 (72.0%) | 0.090 | 18 (72.0%) | 7 (36.8%) | 0.020 |
| Yes | 128 (27.5%) | 19 (43.2%) | 52 (15.1%) | 7 (28.0%) | 7 (28.0%) | 12 (63.2%) | |||
| GERD or PPI/H2RA use | |||||||||
| No | 294 (62.7%) | 18 (40.9%) | 0.005 | --- | --- | --- | --- | --- | --- |
| Yes | 175 (37.3%) | 26 (59.1%) | --- | --- | --- | --- | |||
| NSAID or ASA use | |||||||||
| None | 431 (92.1%) | 41 (93.2%) | 0.924 | 322 (93.1%) | 23 (92.0%) | 0.922 | 23 (92.0%) | 18 (94.7%) | 1.00 |
| Less than daily | 3 (0.6%) | 0 (0.0%) | 2 (0.6%) | 0 (0.0%) | 0 (0.0%) | 0 (0.0%) | |||
| At least daily | 32 (6.8%) | 3 (6.8%) | 20 (5.8%) | 2 (8.0%) | 2 (8.0%) | 1 (5.3%) | |||
| Missing | 3 (0.5%) | 0 (0.0%) | 2 (0.6%) | 0 (0.0%) | 0 (0.0%) | 0 (0.0%) | |||
| Circumference BE Length, mean (cm, SD) | --- | --- | --- | --- | --- | --- | 1.5 (3.1) | 1.2 (2.5) | 0.359 |
| Maximum BE Length, mean (cm, SD) | --- | --- | --- | --- | 2.28 (3.1) | 2.5 (2.7) | 0.613 | ||
| Dysplasia (low grade or high grade) | |||||||||
| No | --- | --- | --- | --- | 20 (80.0%) | 17 (89.5%) | 0.680 | ||
| Yes | --- | --- | --- | --- | 5 (20.0%) | 2 (10.5%) | |||