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. 2020 Dec 18;10:22346. doi: 10.1038/s41598-020-79170-9

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Discontinuation relapse interaction effect: (a) Depicted are clusters for significant interactions between discontinuation and relapse between our choosen seed in the right dorsolateral prefrontal cortex (dlPFC, magenta) and the parietal cortex (red) and the posterior cingulate cortex (PCC, green) and a paired t-test in non-relapsers only for RSFC between right dlPFC and the parietal cortex (blue). (b–d) The Fisher z-transformed average functional connectivity between the right dlPFC and the surviving clusters in the parietal cortex and the PCC is depicted for the interaction between relapsers and non-relapsers (b, d, respectively). Specifically, depicted are significant interaction effects with p < 0.0083 which survive our threshold corrected for multiple comparison. Exact p values are given in Table 2. (c) The paired post-hoc t-test in non-relapsers for the interaction effect in relation to the parietal cortex shown in (b). Error bars indicate standard errors.