Table 3.
Relative change in the concentration of the identified metabolites.
| Metabolite | Percentage change in concentration (%) | Bonferroni corrected T-test | ||||
|---|---|---|---|---|---|---|
| TB vs. PnP | TB vs. LTBI | TB vs. Uninfected | TB vs. PnP | TB vs. LTBI | TB vs. uninfected | |
| Aminoadipic | − 67.0 | 17.3 | 82.9 | 0.0013 | 0.6450 | 0.0975 |
| Citrate | 66.2 | − 36.7 | − 59.6 | 0.0881 | 0.0162 | 0.0001 |
| Creatine | − 30.3 | 102.7 | 21.6 | 0.2690 | 0.0407 | 0.4470 |
| Creatinine | 91.6 | − 19.4 | − 32.3 | 0.0012 | 0.1790 | 0.0013 |
| Glucose | 37.8 | − 24.6 | − 7.9 | 0.3720 | 0.0073 | 0.7080 |
| Mannitol | − 47.7 | 18.1 | 78.8 | 0.1070 | 0.2620 | 0.0436 |
| Phenylalanine | − 33.4 | 60.4 | 33.5 | 0.0262 | 0.0321 | 0.0626 |
| Hippurate | 34.8 | − 23.3 | − 49.6 | 0.2700 | 0.4720 | 0.0132 |
TB, tuberculosis; PnP, pneumococcal pneumonia; LTBI, latent TB infection; uninfected, individuals without infection; PC: Principal Component.
Bold values, statistical significance was determined using a Bonferroni corrected Student's t-test assuming significant unequal corrected variance with p < 0.05.