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. 2020 Dec 18;10:22294. doi: 10.1038/s41598-020-79448-y

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Histological analysis of the 3D MgHA/Coll scaffolds with both MG63 and SAOS-2 cells. The images highlight the morphological features and the interaction behaviour of the sarcospheres and parental cells with the MgHA/Coll material. On the right, it is possible to observe an image enlargement of 200 µm of the spheroidal phenotype of the sarcospheres.