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. 2020 Dec 18;11:6411. doi: 10.1038/s41467-020-20092-5

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — a Expression profiles of cell marker genes that are specific or enriched in the parenchymal clusters. Genes validated by ISH are marked in red. b Double FISH of parenchymal cathepsin B (Smp_141610) with a known marker of differentiated gut, cathepsin B’ (Smp_103610), MIP. No expression of parenchymal cathepsin B is observed in the primordial gut. gc: germinal cell cluster. c WISH of parenchymal cathepsin B in adult males. d–f FISH of parenchymal cathepsin B in different regions of adult worms: d testes lobes, e gut, and f vitellaria. White arrows indicate positive cells. Single confocal sections shown. g, h lap (Smp_030000) is expressed in both parenchyma and in the g gut primordia as well as h adult gut, shown by double FISH with the gut cathepsin B (Smp_103610). i Schematic that summarises the parenchymal cell populations in 2-day schistosomula. Marker genes identified in the current study are indicated in red. All previously reported genes are shown in black. The numbers of ISH experiments performed for each gene are listed in ‘Methods’ and Supplementary Data 7.