Table 2.

LDSC Heritability Enrichment of Each Gene Set Annotation Within the Full Baseline + LD Model for the Four Smoking Phenotypes and One Control Trait Across the Two Smoking Gene Sets and Three Control Gene Sets

Trait	Gene set	Proportion of SNPs in annotation	h 2 SNP proportion	h 2 SNP proportion SE	Enrichment	Enrichment SE	p
Age of initiation	Nicotinic	0.008	0.016	0.004	1.840	0.467	.075
Cigarettes per day	Nicotinic	0.008	0.028	0.009	3.274	1.092	.045
Drinks per week	Nicotinic	0.008	0.013	0.002	1.593	0.240	.014
Smoking cessation	Nicotinic	0.008	0.022	0.005	2.640	0.628	.010*
Smoking initiation	Nicotinic	0.008	0.020	0.005	2.375	0.601	.024
Age of initiation	Smokescreen	0.054	0.098	0.013	1.811	0.242	.001*
Cigarettes per day	Smokescreen	0.054	0.121	0.019	2.238	0.356	.001*
Drinks per week	Smokescreen	0.054	0.079	0.013	1.471	0.236	.049
Smoking cessation	Smokescreen	0.054	0.075	0.006	1.401	0.114	<.001*
Smoking initiation	Smokescreen	0.054	0.100	0.016	1.851	0.295	.006*
Age of initiation	Height	0.030	0.027	0.006	0.914	0.212	.686
Cigarettes per day	Height	0.030	0.035	0.007	1.169	0.249	.494
Drinks per week	Height	0.030	0.029	0.004	0.973	0.137	.846
Smoking cessation	Height	0.030	0.030	0.004	1.020	0.135	.884
Smoking initiation	Height	0.030	0.027	0.008	0.912	0.255	.731
Age of initiation	ALZ	0.043	0.072	0.012	1.685	0.286	.015
Cigarettes per day	ALZ	0.043	0.039	0.007	0.910	0.160	.573
Drinks per week	ALZ	0.043	0.053	0.007	1.243	0.162	.137
Smoking cessation	ALZ	0.043	0.050	0.005	1.171	0.128	.183
Smoking initiation	ALZ	0.043	0.039	0.010	0.905	0.225	.675
Age of initiation	IBD	0.012	0.016	0.007	1.350	0.606	.564
Cigarettes per day	IBD	0.012	0.017	0.005	1.443	0.417	.284
Drinks per week	IBD	0.012	0.018	0.004	1.565	0.341	.104
Smoking cessation	IBD	0.012	0.020	0.007	1.713	0.575	.217
Smoking initiation	IBD	0.012	0.021	0.010	1.841	0.888	.345

LDSC = linkage disequilibrium–score regression.

*p < .01, the within-trait Bonferroni correction for multiple testing.