Fig. 2.

Total Body Irradiation box, phantom design and dosimetry. (A) The acrylate box can be covered by the lid which allows breathing of the mice. Unanesthetized mice can walk freely during radiation. (B) Phantoms are positioned at different positions/orientations (C) Near cylindrical phantoms represent the body of mice. The phantoms are sized 25 × 25 × 50 mm, in which radiochromic film fits in a slit in the middle. (D) Target box: dose profile measurement setup in 12 mouse phantoms covered with 7 cm lead. (E) An example of the dose profile along a yellow line in figure (D) (F) TBI box: 2D-dose distribution for AP and AP-PA treatment technique as measured with EBT film oriented along the photon beam axis. (G) TBI-box: Absolute dose variation as function of distances between mouse phantoms. (For interpretation of the references to color in this figure legend, the reader is referred to the web version of this article.)