Fig. 4.

Phylogenetic profiling of superfamily members. Distribution of M protein and Orf3a homologs across a representative tree of Coronaviridae. (a): Genome-based tree of 89 representative strains of coronaviruses, 89 nodes are shown and only 45 labels, for clarity; groups and corresponding nodes are color-coded as grey (alpha), orange (beta), yellow (gamma) and lavender (delta), coded in a vertical bar labeled as ‘group’; the eleven strains of the beta group containing both M protein and Orf3a homologs are coded in the vertical bar in cyan and labeled as ‘bothMOrf3a’. (b): Depiction of the representative tree with a zoom focus on the 11 strains that contain both families. (c): Section of the tree with the 11 strains that contain both families listed. For all labels, sequence identifier precedes description of the genome sequence for the corresponding strain. (For interpretation of the references to color in this figure legend, the reader is referred to the web version of this article.)