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Binding of FGF23 variants to sKLA
| KD (nM) | kon (×105 M−1 s−1) | koff (×10−3 s−1) | |
| FGF23-WT | 14 ± 3 | 2.6 ± 0.5 | 3.4 ± 0.1 |
| FGF23-CS | 18 ± 4 | 2.3 ± 0.4 | 4.2 ± 0.4 |
| FGF23 D188A | 13 ± 3 | 2.8 ± 0.5 | 3.6 ± 0.2 |
| FGF23-CS D188A | 18 ± 3 | 2.5 ± 0.3 | 4.4 ± 0.3 |
| FGF23 D188A D222A* | n/a | n/a | n/a |
No binding detected (no change in BLI signal).
