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. 2020 Nov 30;117(50):32145–32154. doi: 10.1073/pnas.2009680117

Fig. 3.

Fig. 3.

Oral administration of OLT1177 in APP/PS1 animals for 3 mo restores dendritic spine loss to WT conditions. (A and B) Dendritic spine density of CA1-apical and -basal was not changed in WT mice following administration of 3.75 g/kg and 7.5 g/kg OLT1177. (C and D) Spine density in both apical and basal dendrites of CA1 hippocampal neuron was significantly diminished in APP/PS1 mice treated either with control food or 3.75 g/kg OLT1177. Administration of 7.5 g/kg OLT1177 could rescue the phenotype in APP/PS1 mice (WT vs. APP/PS1 P = 0.001, WT vs. APP/PS1 3.75 g/kg P = 0.001, WT vs. APP/PS1 7.5 g/kg P = 0.89, APP/PS1 vs. APP/PS1 7.5 g/kg P = 0.001 in C; WT vs. APP/PS1 P = 0.001, WT vs. APP/PS1 3.75 g/kg P = 0.001, WT vs. APP/PS1 7.5 g/kg P = 0.36, APP/PS1 vs. APP/PS1 7.5 g/kg P = 0.001 in D). Representative images of dendritic spines of hippocampal CA1 neurons in the tested groups are presented. (Scale bars, 5 µm.) Data are presented as mean ± SEM. ***P < 0.001 compared to WT, +++P < 0.001 compared to APP/PS1 (n = 5 animals and n = 8 dendrites).