Fig. 5.
NLPITE+MOG suppresses acute EAE in C57BL/6J mice. EAE was induced in B6 mice with MOG35–55, and NLPs were administered following various treatment regimens. (A) Clinical scores of mice treated SC with NLPs once a week beginning the day after disease induction. (B) Clinical scores of mice treated IV with NLPs administered once on day 7 after disease. (C) Clinical scores of mice treated IV with NLPs administered once on day 15 after disease. (D) Clinical scores of mice treated daily IV with NLPs for 3 d 1 mo prior, 2 wk prior, 1 wk prior, 1 d prior, or a single injection 1 wk after EAE induction. Data are mean ± SEM (n = 5 mice per group). *P < 0.05, **P < 0.01, ****P < 0.0001, two-way repeated measures ANOVA followed by Tukey’s multiple comparison test.