Figure 8.

Brain histopathology; Group 3: group of experimentally inducted and treated by U. pumila extract (150 mg/kg), cerebral cortex (A), subiculum in hippocampus (B), fascia dentata and hilus in hippocampus (C), striatum (D) and cerebellum (E). (H&E staining, x10, scale bar = 50μm). U. pumila extract (150 mg/kg b.wt.) caused limited nuclear pyknosis and degeneration in cerebral cortex with no histopathological alteration in the subiculum in hippocampus. The fascia dentata and hilus in hippocampus showed few neurons with nuclear pyknosis and degeneration. Striatum with multiple focal small eosinophilic plagues formation with loss of the neurons was observed (indicated by white arrows). The cerebellum had no histopathological alteration.