Table 1.
Effect U. pumila extract on oxidative stress status in brain-homogenate and sera in AlCl3-induced AD rats.
| GROUPS | BRAIN HOMOGENATE |
SERUM |
|||||
|---|---|---|---|---|---|---|---|
| MDA (nmol/g. tissue) | GSH (mmol/g. tissue) | CAT (U/g. tissue) | SOD (U/g. tissue) | MDA (nmol/mg protein) | GSH (nmol/mg protein) | CAT (U/mg protein) | |
| NORMAL GROUP | 0.5 ± 0.3 | 0.7 ± 0.01 | 2.61 ± 0.05 | 31.88 ± 0.4 | 0.55 ± 0.023 | 0.61 ± 0.04 | 2.34 ± 0.07 |
| AD GROUP | 2.14 ± 0.4∗ | 0.23 ± 0.06 ∗ | 1.9 ± 0.06∗ | 21.06 ± 0.5∗ | 1.35 ± 0.13 ∗ | 0.32 ± 0.02∗ | 1.74 ± 0.08 ∗ |
| U. PUMILA EXTRACT TREATED GROUP | 1.05 ± 0.21@# | 0.63 ± 0.1@# | 2.22 ± 0.18 @# | 33.24 ± 4.3@# | 0.97 ± 0.06 @# | 0.4 ± 0.05 @# | 2.05 ± 0.05 @# |
| REF. DRUG TREATED GROUP | 0.88 ± 0.08@ | 0.71 ± 0.05@ | 2.33 ± 0.47@ | 38.16 ± 1.4@ | 1.12 ± 0.03@ | 0.46 ± 0.021@ | 2.18 ± 0.04@ |
All data are represented as Mean ± SEM at N = 6. ∗ Significance change from control group at p < 0.05. @ Significance change from AD group at p < 0.05. # Significance change from Distigmine group at p < 0.05. (%): Percent of difference from control group.