Fig. 7.

Correlation of the biomarkers (Cluster of Differentiation [CD] 3, CD8; Angiopoietin [ANG] 2; microvessel density [MVD]) with the expression of the genes within the progressive disease (PD)-like signature for tumor samples. Each column is a gene selected among the most differentially expressed between treatment and baseline (p-value > 0.05 and log-fold change > 0.5). The genes are sorted from left to right, from the highest to the lowest log-fold change. The DN category indicates genes with a negative log-fold change (decreased expression in treated samples). Rows are the biomarker measurements. Cells are colored when there is a moderate to high correlation. A red cell indicates a Spearman correlation higher than 0.3, and a blue cell indicates a Spearman correlation inferior to 0.3 (n = 18).