Table 2.

A Summary of individual cases reporting CLOCC in context of SARS-CoV-2 infection.

Author(s)	Age/Sex	Clinical presentation	Confirmed SARS-CoV-2 serology/RT-PCR	MRI findings	Outcome
Kakadia Do et al. [15]	69/M	Disorientation, inattention, bradyphrenia, fever	Elevated SARS-CoV-2 IgM and IgG antibodies	Hyperintensity in SCC	Complete resolution of neurological symptoms and corpus callosum lesion after 2 weeks
Agarwa et al. [16]	73/M	Altered consciousness, fever, and respiratory distress	PCR positive for SARS-CoV-2	Isolated lesion in SCC	Improved and stepped down from ICU after 4 weeks. No documentation about resolution of corpus callosum lesion or neurological status follow-up
Hayashi et al. [17]	75/M	Altered sensorium, tremors, ataxia, and urinary incontinence	PCR positive for SARS-CoV-2	Abnormal hyperintensity in SCC	Neurological symptoms resolved after 3 days. Patient died after 12 days secondary to respiratory failure
Moreau et al. [18]	26/M	Acute confusion, agitation, inappropriate speech, fever, dry cough	Positive SARS-CoV-2 IgG	Hyperintense round lesion in SCC	Neurological status improved within 48 h and his cardiac dysfunction resolved within 1 week. Follow-up MRI showed resolution of the corpus callosum lesion
Forestier et al. [7]	55/M	Headache, high-grade fever, dizziness and impaired consciousness	PCR positive for SARS-Cov-2	Increased diffusion-weighted signal in SCC	Improved and extubated 17 days later, follow up MRI showed complete regression of the corpus callosum lesion

CLOCC – cytotoxic lesions of corpus callosum; SCC – splenium of corpus callosum; RT-PCR – real-time reverse transcription polymerase chain reaction test; SARS-CoV-2 – severe acute respiratory syndrome coronavirus 2.