Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2020 Jun 19;15(12):2186–2194. doi: 10.4103/1673-5374.284977

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright: © 2020 Neural Regeneration Research

This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms.

PMC Copyright notice

Schematic of p62 domains.

p62 self-oligomerizes via its PB1 domain. The LC3-interacting region (LIR) is required for p62 binding to the autophagosome membrane protein LC3, and p62 binds to ubiquitinated substrates via the ubiquitin associated (UBA) domain. p62 regulates Nrf2 signaling through interaction with inhibitory protein Keap1 via the Keap1 interacting region (KIR) domain, and regulates nuclear factor-kappa B (NF-κB) signaling via TRAF6 binding through the TRAF6 binding sequence (TBS) and interaction with RIP via the ZZ domain (Ichimura and Komatsu, 2018).