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. Author manuscript; available in PMC: 2020 Dec 19.
Published in final edited form as: Clin Sci (Lond). 2020 Jul 17;134(13):1751–1762. doi: 10.1042/CS20200575

Figure 6. Neutralizing HMGB1 attenuates renal cell death 24 h post-IR in male, but not female SHR.

Figure 6.

Cell death was measured by TUNEL staining in kidneys collected 24 h post-IR in 13 week old male and female SHR treated with control IgG or HMGB1 neutralizing antibody 1 h prior to IR. Brown nuclei with black arrows indicate TUNEL-positive cells. Representative images are shown in (A) with mean quantification data in (B). Data are expressed as mean ± SEM, n=5 rats in each group with individual animal data indicated by the symbols. Open symbols indicate control IgG-treated animals, filled symbols indicate anti-HMGB1-treated animals, males are represented by squares and females by circles. Data were compared via two-way ANOVA with P<0.05 considered significant.