Table 4.
Results from multivariate cox models
| Variables | Overall mortality (inverse of OS) | Treatment failure (inverse of PFS) | ||
|---|---|---|---|---|
| Hazard ratio (95% confidence interval) | P value | Hazard ratio (95% confidence interval) | P value | |
| Weight change c | <0.001 a | <0.001 a | ||
| Gained | 1 | 1 | ||
| Lost <2% | 1.05 (0.86–1.29) | 0.625 | 1.24 (1.01–1.51) | 0.036 |
| Lost ≥2% | 1.66 (1.33–2.07) | <0.001 | 1.54 (1.24–1.91) | <0.001 |
| Sex | ||||
| Female | 1 | 1 | ||
| Male | 1.46 (1.23–1.73) | <0.001 | 1.36 (1.49–1.60) | <0.001 |
| Age | ||||
| <65 years | 1 | 1 | ||
| ≥65 years | 0.89 (0.74–1.08) | 0.239 | 0.80 (0.66–097) | 0.020 |
| Baseline BMI | 0.033 a | 0.246 a | ||
| Normal | 1 | 1 | ||
| Underweight | 0.92 (0.58–1.44) | 0.702 | 1.14 (0.72–1.78) | 0.583 |
| Overweight | 0.80 (0.66–0.96) | 0.020 | 0.89 (0.74–1.08) | 0.242 |
| Obese | 0.73 (0.58–0.93) | 0.010 | 0.82 (0.65–1.02) | 0.079 |
| Performance score | 0.001 a | 0.059 a | ||
| 0 | 1 | 1 | ||
| 1 | 1.27 (1.06–1.53) | 0.011 | 1.20 (1.00–1.43) | 0.046 |
| ≥2 | 2.24 (1.60–3.12) | <0.001 | 1.37 (0.99–1.89) | 0.059 |
| Trial/arm b | 0.003 | 0.013 | ||
BMI, body mass index; OS, overall survival; PFS, progression‐free survival.
a
Overall P value.
b
Due to a large number of combinations, HRs (hazard ratios) by trial/arm combinations are not listed.
c
Weight lost ≥2% vs. lost <2%: Overall mortality HR (95% CI) = 1.57 (1.27–1.95), P < 0.001; Treatment failure HR (95% CI) = 1.24 (1.01–1.53), P = 0.037.