Table 4.
Viral load outcomes at 12 and 24 months, with risk differences calculated using generalized estimating equations
| Intention to treat a | Modified intention to treat b | Completed viral load | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 12 months | ||||||||||||
| SoC (N = 1173) | Intervention (N = 977) | ICC | RD (95% CI) | SoC (N = 1167) | Intervention (N = 975) | ICC | RD (95% CI) | SoC (N = 1107) | Intervention (N = 956) | ICC | RD (95% CI) | |
| n (%) | n (%) | n (%) | n (%) | n (%) | n (%) | |||||||
| Viral load completed | 1107 (94.4%) | 956 (97.9%) | 0.166 | 3.8% (0.3 to 7.2) | 1106 (94.8%) | 955 (97.9%) | 0.178 | 3.5% (0 to 6.9) | — | — | ||
| Viral load suppressed | 1065 (90.8%) | 933 (95.5%) | 0.111 | 5.1% (1.3 to 8.9) | 1064 (91.2%) | 932 (95.6%) | 0.115 | 4.8% (1 to 8.6) | 1065 (96.2%) | 933 (97.6%) | 0.019 | 1.5% (−0.3 to 3.2) |
| 24 months | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SoC (N = 1173) | Intervention (N = 977) | ICC | RD (95% CI) | SoC (N = 1160) | Intervention (N = 963) | ICC | RD (95% CI) | SoC (N = 999) | Intervention (N = 887) | ICC | RD (95% CI) | |
| Viral load completed | 999 (85.2%) | 887 (90.8%) | 0.062 | 5.5% (1.5 to 9.5) | 996 (85.9%) | 879 (91.3%) | 0.061 | 5.3% (1.4 to 9.2) | — | — | ||
| Viral load suppressed | 969 (82.6%) | 853 (87.3%) | 0.058 | 4.6% (0.2 to 9.0) | 967 (83.4%) | 847 (88.0%) | 0.059 | 4.5% (0.2 to 8.9) | 969 (97%) | 853 (96.2%) | 0.008 | −0.8% (−2.5 to 0.9) |
CI, confidence interval; ICC, intra‐cluster correlation; RD, risk difference; SoC, standard of care.
a
All enrolled are included in the denominators
b
All enrolled except those transferred out of clinic before the end of time period are included in denominator.