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. 2020 Oct 13;11(6):1509–1524. doi: 10.1002/jcsm.12627

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© 2020 The Authors. Journal of Cachexia, Sarcopenia and Muscle published by John Wiley & Sons Ltd on behalf of Society on Sarcopenia, Cachexia and Wasting Disorders

This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.

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Levels of cachexia‐related factors produced by pancreatic tumour organoids. (A) mRNA expression of cachexia‐related genes was determined in human pancreatic tumour organoids from each individual patient. When two organoid cultures were established from one individual tumour biopsy (organoid Medium ‘a’ or Medium ‘b’), the mRNA expression of both organoid cultures are shown. Data were normalized to CYPA and B2M reference genes. (B) mRNA expression of cachexia‐related genes grouped by the cachexia status of the patients. Results are presented as mean ± SE (Mann–Whitney U test, *P < 0.05).